Variable effects of vitamin E on Drosophila longevity.
Identifieur interne : 004367 ( Main/Exploration ); précédent : 004366; suivant : 004368Variable effects of vitamin E on Drosophila longevity.
Auteurs : Christopher Driver [Australie] ; Angela GeorgeouSource :
- Biogerontology [ 1389-5729 ] ; 2003.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Antioxydants (administration et posologie), Antioxydants (métabolisme), Antioxydants (pharmacologie), Drosophila melanogaster (effets des médicaments et des substances chimiques), Drosophila melanogaster (physiologie), Espérance de vie (MeSH), Herbicides (toxicité), Humains (MeSH), Mâle (MeSH), Paraquat (toxicité), Rythme circadien (effets des médicaments et des substances chimiques), Vieillissement (effets des médicaments et des substances chimiques), Vitamine E (administration et posologie), Vitamine E (métabolisme), Vitamine E (pharmacologie).
- MESH :
- administration et posologie : Antioxydants, Vitamine E.
- effets des médicaments et des substances chimiques : Drosophila melanogaster, Rythme circadien, Vieillissement.
- métabolisme : Antioxydants, Vitamine E.
- pharmacologie : Antioxydants, Vitamine E.
- physiologie : Drosophila melanogaster.
- toxicité : Herbicides, Paraquat.
- Animaux, Espérance de vie, Humains, Mâle.
English descriptors
- KwdEn :
- Aging (drug effects), Animals (MeSH), Antioxidants (administration & dosage), Antioxidants (metabolism), Antioxidants (pharmacology), Circadian Rhythm (drug effects), Drosophila melanogaster (drug effects), Drosophila melanogaster (physiology), Herbicides (toxicity), Humans (MeSH), Life Expectancy (MeSH), Male (MeSH), Paraquat (toxicity), Vitamin E (administration & dosage), Vitamin E (metabolism), Vitamin E (pharmacology).
- MESH :
- chemical , administration & dosage : Antioxidants, Vitamin E.
- drug effects : Aging, Circadian Rhythm, Drosophila melanogaster.
- chemical , metabolism : Antioxidants, Vitamin E.
- chemical , pharmacology : Antioxidants, Vitamin E.
- physiology : Drosophila melanogaster.
- chemical , toxicity : Herbicides, Paraquat.
- Animals, Humans, Life Expectancy, Male.
Abstract
Vitamin E has been used widely in invertebrate experiments where it usually acts to prolong life span. Conversely in vertebrates it has been less successful. In some cases, experiments in rodents show no effect of vitamin E on longevity. Consequently, the suggestion has been made that anti-oxidants do not effect ageing in vertebrates. In more extensive experiments with Drosophila melanogaster, vitamin E exerted both life span extending and toxic effects. At 20 micro g/ml, the life span was increased by 16%, although there was no effect at higher or lower concentrations. At 200 micro g/ml, vitamin E protected Drosophila against paraquat toxicity. At this concentration, vitamin E had no effect on longevity in one set of experiments, and shortened the life span in another set. Apparent toxicity of vitamin E was also observed in behavior experiments. We suggest that inactivity of vitamin E that has been reported by some authors is due to antagonistic actions of a toxic effect and a beneficial anti-oxidant action. This complex response to vitamin E will limit its use for clinical and investigative work on ageing.
DOI: 10.1023/a:1023347803932
PubMed: 12766533
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Box 35, Poplar Rd, Parkville, VIC 3052</wicri:regionArea><wicri:noRegion>VIC 3052</wicri:noRegion></affiliation></author><author><name sortKey="Georgeou, Angela" sort="Georgeou, Angela" uniqKey="Georgeou A" first="Angela" last="Georgeou">Angela Georgeou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12766533</idno><idno type="pmid">12766533</idno><idno type="doi">10.1023/a:1023347803932</idno><idno type="wicri:Area/Main/Corpus">004462</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">004462</idno><idno type="wicri:Area/Main/Curation">004462</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">004462</idno><idno type="wicri:Area/Main/Exploration">004462</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Variable effects of vitamin E on Drosophila longevity.</title><author><name sortKey="Driver, Christopher" sort="Driver, Christopher" uniqKey="Driver C" first="Christopher" last="Driver">Christopher Driver</name><affiliation wicri:level="1"><nlm:affiliation>The National Ageing Research Institute, P.O. 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Conversely in vertebrates it has been less successful. In some cases, experiments in rodents show no effect of vitamin E on longevity. Consequently, the suggestion has been made that anti-oxidants do not effect ageing in vertebrates. In more extensive experiments with Drosophila melanogaster, vitamin E exerted both life span extending and toxic effects. At 20 micro g/ml, the life span was increased by 16%, although there was no effect at higher or lower concentrations. At 200 micro g/ml, vitamin E protected Drosophila against paraquat toxicity. At this concentration, vitamin E had no effect on longevity in one set of experiments, and shortened the life span in another set. Apparent toxicity of vitamin E was also observed in behavior experiments. We suggest that inactivity of vitamin E that has been reported by some authors is due to antagonistic actions of a toxic effect and a beneficial anti-oxidant action. This complex response to vitamin E will limit its use for clinical and investigative work on ageing.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12766533</PMID><DateCompleted><Year>2003</Year><Month>09</Month><Day>12</Day></DateCompleted><DateRevised><Year>2019</Year><Month>11</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1389-5729</ISSN><JournalIssue CitedMedium="Print"><Volume>4</Volume><Issue>2</Issue><PubDate><Year>2003</Year></PubDate></JournalIssue><Title>Biogerontology</Title><ISOAbbreviation>Biogerontology</ISOAbbreviation></Journal><ArticleTitle>Variable effects of vitamin E on Drosophila longevity.</ArticleTitle><Pagination><MedlinePgn>91-5</MedlinePgn></Pagination><Abstract><AbstractText>Vitamin E has been used widely in invertebrate experiments where it usually acts to prolong life span. Conversely in vertebrates it has been less successful. In some cases, experiments in rodents show no effect of vitamin E on longevity. Consequently, the suggestion has been made that anti-oxidants do not effect ageing in vertebrates. In more extensive experiments with Drosophila melanogaster, vitamin E exerted both life span extending and toxic effects. At 20 micro g/ml, the life span was increased by 16%, although there was no effect at higher or lower concentrations. At 200 micro g/ml, vitamin E protected Drosophila against paraquat toxicity. At this concentration, vitamin E had no effect on longevity in one set of experiments, and shortened the life span in another set. Apparent toxicity of vitamin E was also observed in behavior experiments. We suggest that inactivity of vitamin E that has been reported by some authors is due to antagonistic actions of a toxic effect and a beneficial anti-oxidant action. 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